Peptidyl Arginine deiminase type-2

E6764Hu

Sandwich

48T,96T

3.55ng/L

7-1500ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Protein-arginine deiminase type-2 is an enzyme that in humans is encoded by the PADI2 gene. This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.

75,564

11240

PAD2;PAD-H19;PADI2;PDI2;Peptidylarginine deiminase II;Protein-arginine deiminase type II;Protein-arginine deiminase type-2

PADI2

Neuroscience; Signal Transduction; Epigenetics and Nuclear Signaling; Metabolism

PADI2