Full product name
Retinoic Acid Receptor Alpha
Code
E3952Hu
Assay type
Sandwich
Size
48T,96T
Sensitivity
0.022ng/ml
Detection range
0.05-15ng/ml
Sample type
Serum, plasma, cell culture supernates
Species
Human
Storage
2-8ºC
Assay time
1h 30m
Background
Receptor for retinoic acid (PubMed: 19850744, PubMed: 16417524, PubMed: 20215566). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed: 28167758). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed: 28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed: 16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed: 9267036, PubMed: 19850744, PubMed: 20215566). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed: 28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed: 28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed: 28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed: 28167758).
UniProt accession
MASS（Da）
50,771
GeneID
5914
Synonyms
Nuclear receptor subfamily 1 group B member 1;RARA;RAR-alpha;Retinoic acid receptor alpha
Gene names
RARA
Research area
Epigenetics and Nuclear Signaling
Target protein
RARA
