Calsyntenin 1

E7326Hu

Sandwich

48T,96T

12.32ng/L

20-3800ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).

109,793

22883

Alcadein-alpha;ALC-ALPHA;alcalpha2;Alzheimer-related cadherin-like protein;Calsyntenin-1;CDHR12;CLSTN1;CST-1;CSTN1;C-terminal fragment 1-alpha];CTF1-alpha;Non-classical cadherin XB31alpha;PIK3CD;SAlc-alpha;Soluble Alc-alpha;XB31alpha

CLSTN1

Neuroscience

CLSTN1