C-Type Lectin Domain Family 7 Member A

E4020hu

Sandwich

48T,96T

9.14ng/L

20-4500ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).

27,627

64581

Beta-glucan receptor;CD antigen CD369;CLEC7A;C-type lectin domain family 7 member A;C-type lectin superfamily member 12;DC-associated C-type lectin 1;Dectin-1;Dendritic cell-associated C-type lectin 1

CLEC7A

Immunology

CLEC7A