Kappa-Type Opioid Receptor

E4216hu

Sandwich

48T,96T

0.019ng/ml

0.05-15ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

42,645

4986

Kappa-type opioid receptor;KOR-1;K-OR-1;OPRK 1;OPRK1

OPRK1

Others

OPRK1