Coiled Coil and C2 Domain Containing Protein 1A

E4454Hu

Sandwich

48T,96T

0.022ng/ml

0.05-20ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.

104,062

54862

Akt kinase-interacting protein 1;CC2D1A;Coiled-coil and C2 domain-containing protein 1A;Five prime repressor element under dual repression-binding protein 1;FRE under dual repression-binding protein 1;Freud-1;Putative NF-kappa-B-activating protein 023N

CC2D1A

Others

CC2D1A