C-C Motif Chemokine 5

E5009Hu

Sandwich

48T,96T

5.26ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed: 16791620, PubMed: 1380064, PubMed: 8525373, PubMed: 9516414, PubMed: 15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed: 23979485).

9,990

6352

C-C motif chemokine 5;CCL 5;CCL5;EoCP;Eosinophil chemotactic cytokine;RANTES(3-68;RANTES(4-68;SIS-delta;Small-inducible cytokine A5;T cell-specific protein P228;T-cell-specific protein RANTES;TCP228

CCL5

Immunology; Cardiovascular

CCL5