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Home > Product > ELISA Kit > Human Cd160 Antigen, CD160 ELISA Kit

Human Cd160 Antigen, CD160 ELISA Kit

Human Cd160 Antigen, CD160 ELISA Kit

Product Summary

Size: 48T,96T

Sensitivity: 0.14ng/ml

Detection range: 0.3-90ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Product Summary

Size: 48T,96T

Sensitivity: 0.14ng/ml

Detection range: 0.3-90ng/ml

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Product overview

Full product name

Cd160 Antigen

Code

E5015Hu

Assay type

Sandwich

Size

48T,96T

Sensitivity

0.14ng/ml

Detection range

0.3-90ng/ml

Sample type

Serum, plasma, cell culture supernates

Species

Human

Storage

2-8ºC

Assay time

1h 30m

Background

[CD160 antigen]: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed: 19109136, PubMed: 11978774, PubMed: 17307798). Receptor for both classical and non-classical MHC class I molecules (PubMed: 9973372, PubMed: 12486241). In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed: 12486241). On CD8+ T cells, binds HLA-A2-B2M in complex with a viral Peptide and provides a costimulatory signal to activated/memory T cells (PubMed: 9973372). Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed: 25255144). On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed: 16809620). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed: 18193050). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity). [CD160 antigen, soluble form]: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions.

UniProt accession

MASS(Da)

19,810

GeneID

11126

Synonyms

CD 160;CD antigen CD160;CD160;CD160 antigen;CD160 antigen, soluble form;Natural killer cell receptor BY55

Gene names

CD160

Research area

Immunology

Target protein

CD160

Components

Components Quantity
Pre-coated ELISA Plate 12 * 8 well strips x1
Standard solution 0.5ml x1
Standard diluent 3ml x1
Streptavidin-HRP 6ml x1
Stop solution 6ml x1
Substrate solution A 6ml x1
Substrate solution B 6ml x1
Wash buffer concentrate (25x) 20ml x1
Biotinylated antibody 1ml x1

Protocol data

These standard curves of Human Cd160 Antigen, CD160 ELISA Kit are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration O.D. Average Corrected
48ng/ml 2.043 2.125 2.099
2.206
24ng/ml 1.48 1.446 1.421
1.412
12ng/ml 0.614 0.635 0.61
0.656
6ng/ml 0.344 0.394 0.368
0.444
3ng/ml 0.143 0.155 0.13
0.168
0ng/ml 0.025 0.025 0
0.025

Precision

We measured random samples of E5015Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay Sample n Mean Standard Deviation CV%
Intra-Assay 1 18 13.8 0.65 4.7
Intra-Assay 2 18 28.4 1.25 4.4
Intra-Assay 3 18 10.7 0.42 4

Protocols

References

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Product size

Price

  • 48T

    $320.00

  • 96T

    $458.00

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Lead time: Within one week

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