Nuclear Inhibitor of Protein Phosphatase 1

E5794Hu

Sandwich

48T,96T

9.19ng/L

20-4500ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.

38,479

5511

ARD-1;NIPP-1;Nuclear inhibitor of protein phosphatase 1;PPP 1R8;PPP1R8;Protein phosphatase 1 regulatory inhibitor subunit 8 [Includes: Activator of RNA decay

PPP1R8

Others

PPP1R8