Nucleotide-Binding Oligomerization Domain-Containing Protein 2

E5806Hu

Sandwich

48T,96T

7.18ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed: 18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed: 20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed: 19701189).

115,283

64127

Caspase recruitment domain-containing protein 15;Inflammatory bowel disease protein 1;NOD 2;NOD2;Nucleotide-binding oligomerization domain-containing protein 2

NOD2

Cell Biology

NOD2