Transient Receptor Potential Cation Channel Subfamily A Member 1

E6304Hu

Sandwich

48T,96T

5.09ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Receptor-activated non-selective cation Channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed: 21873995, PubMed: 23199233, PubMed: 25389312, PubMed: 25855297). Shows 8-fold preference for divalent over monovalent cations (PubMed: 31447178). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of irritants, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed: 25389312, PubMed: 27241698, PubMed: 30878828, PubMed: 20547126). Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed: 25389312). Is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction Channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).

127,501

8989

Ankyrin-like with transmembrane domains protein 1;Transformation-sensitive protein p120;Transient receptor potential cation Channel subfamily A member 1;TRPA 1;TRPA1;Wasabi receptor

TRPA1

Others

TRPA1