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Home > Product > ELISA Kit > Human Baculoviral Iap Repeat-containing Protein 3, BIRC3 ELISA Kit

Human Baculoviral Iap Repeat-containing Protein 3, BIRC3 ELISA Kit

Human Baculoviral Iap Repeat-containing Protein 3, BIRC3 ELISA Kit

Product Summary

Size: 48T,96T

Sensitivity: 9.94ng/L

Detection range: 20-4500ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Product Summary

Size: 48T,96T

Sensitivity: 9.94ng/L

Detection range: 20-4500ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Product overview

Full product name

Baculoviral Iap Repeat-Containing Protein 3

Code

E6535Hu

Assay type

Sandwich

Size

48T,96T

Sensitivity

9.94ng/L

Detection range

20-4500ng/L

Sample type

Serum, plasma, cell culture supernates

Species

Human

Storage

2-8ºC

Assay time

1h 30m

Background

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

UniProt accession

MASS(Da)

68,372

GeneID

330

Synonyms

API2;Apoptosis inhibitor 2;Baculoviral IAP repeat-containing protein 3;BIRC 3;BIRC3;Cellular inhibitor of apoptosis 2;C-IAP2;hIAP1;hIAP-1;IAP homolog C;Inhibitor of apoptosis protein 1;RING finger protein 49;RING-type E3 ubiquitin transferase BIRC3;TNFR2-TRAF-signaling complex protein 1

Gene names

BIRC3

Research area

Cell Biology

Target protein

BIRC3

Components

Components Quantity
Pre-coated ELISA Plate 12 * 8 well strips x1
Standard solution 0.5ml x1
Standard diluent 3ml x1
Streptavidin-HRP 6ml x1
Stop solution 6ml x1
Substrate solution A 6ml x1
Substrate solution B 6ml x1
Wash buffer concentrate (25x) 20ml x1
Biotinylated antibody 1ml x1

Protocol data

These standard curves of E6535Hu are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration O.D. Average Corrected
2400ng/L 1.916 1.94 1.898
1.963
1200ng/L 0.877 1.005 0.963
1.133
600ng/L 0.523 0.573 0.531
0.624
300ng/L 0.186 0.227 0.185
0.268
150ng/L 0.084 0.084 0.042
0.083
0ng/L 0.046 0.042 0
0.038

Precision

We measured random samples of E6535Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay Sample n Mean Standard Deviation CV%
Intra-Assay 1 18 623.6 29.28 4.7
Intra-Assay 2 18 1101.2 52.63 4.8
Intra-Assay 3 18 1784.3 48.11 2.7

Protocols

References

Customer reviews and Q&As

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Associated products

  • Size

    Code

    Price

  • 48T

    E6535Hu

    $320.00

  • 96T

    E6535Hu

    $458.00

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Lead time: Within two weeks

We are continuously updating our ELISA Kit catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.

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