Cytochrome P450 2C19

E6615Hu

Sandwich

48T,96T

0.053ng/ml

0.1-40ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed: 18577768, PubMed: 19965576, PubMed: 20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed: 18577768, PubMed: 19965576, PubMed: 20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed: 18577768). Catalyzes the epoxidation of double bonds of PUFA (PubMed: 20972997, PubMed: 19965576). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed: 11950794). Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed: 23959307).

55,931

1557

(R-limonene 6-monooxygenase;(S-limonene 6-monooxygenase;(S-limonene 7-monooxygenase;4'-hydroxylating;CYP2C19;CYPIIC17;CYPIIC19;Cytochrome P450 2C19;Cytochrome P450-11A;Cytochrome P450-254C;Fenbendazole monooxygenase;Mephenytoin 4-hydroxylase

CYP2C19

Others

CYP2C19