Three-Prime Repair Exonuclease 1

E6685Hu

Sandwich

48T,96T

0.013ng/ml

0.05-15ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

33,212

11277

3'-5' exonuclease TREX1;Deoxyribonuclease III;DNase III;Three-prime repair exonuclease 1;TREX 1;TREX1

TREX1

Epigenetics and Nuclear Signaling

TREX1