Transcription Factor A,Mitochondrial

E6726Hu

Sandwich

48T,96T

5.17ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed: 29445193, PubMed: 32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed: 29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed: 20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed: 22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed: 22037172). Is able to unwind DNA (PubMed: 22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed: 1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed: 22841477, PubMed: 19304746). May play a role in organizing and compacting mitochondrial DNA (PubMed: 22037171).

29,097

7019

Mitochondrial transcription factor 1;MtTF1;mtTFA;TCF-6;TFAM;Transcription factor 6;Transcription factor 6-like 2;Transcription factor A, mitochondrial

TFAM

Tags & Cell Markers

TFAM