Pancreas/Duodenum Homeobox Protein 1

E6802Hu

Sandwich

48T,96T

3.58ng/L

7-1500ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

30,771

3651

Glucose-sensitive factor;GSF;IDX-1;Insulin promoter factor 1;Insulin upstream factor 1;IPF-1;Islet/duodenum homeobox-1;IUF-1;Pancreas/duodenum homeobox protein 1;PDX 1;PDX1;PDX-1;Somatostatin-transactivating factor 1;STF-1

PDX1

Signal Transduction

PDX1