Complement C4-A

E6926Hu

Sandwich

48T,96T

0.023μg/ml

0.05-20ug/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

192,785

720721

Acidic complement C4;C 4A;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2;C4A;C4a anaphylatoxin;C4b-A;C4d-A;Complement C4 beta chain;Complement C4 gamma chain;Complement C4-A;Complement C4-A alpha chain

C4A

Others

C4A