Hormone-Sensitive Lipase

E2138Mo

Sandwich

48T,96T

0.024U/mL

0.05-20U/mL

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed: 15550674, PubMed: 20625037, PubMed: 21454566, PubMed: 23066022, PubMed: 23291629). Shows a preferential hydrolysis of DAGs over TAGs and MAGs and of the fatty acid (FA) esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Preferentially hydrolyzes FA esters at the sn-3 position of the glycerol backbone in DAGs (PubMed: 23066022). Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed: 20625037, PubMed: 21454566). In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production (By similarity).

83,348

16890

Hormone-sensitive lipase;HSL;LIPE;Monoacylglycerol lipase LIPE;REH;Retinyl ester hydrolase

LIPE

Metabolism

LIPE