Interleukin-27 Subunit Beta

E2189Mo

Sandwich

48T,96T

0.26ng/L

0.5-200ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

25,353

50498

EBI 3;EBI3;Epstein-Barr virus-induced gene 3 protein homolog;IL-27 subunit beta;IL-27B;Interleukin-27 subunit beta

EBI3

Others

EBI3