Meteorin-Like Protein

E2254Mo

Sandwich

48T,96T

9.91ng/L

20-4500ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.

34,530

210029

Meteorin-like protein;METRNL;Subfatin

METRNL

Cell Biology

METRNL