Toll-Like Receptor 8

E2516Mo

Sandwich

48T,96T

1.55ng/L

3-900ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively.

119,358

170744

CD antigen CD288;TLR 8;TLR8;Toll-like receptor 8

TLR8

Immunology; Microbiology

TLR8