Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1

E2549Mo

Sandwich

48T,96T

9.84ng/L

20-4500ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity).

56,414

19261

Bit;Brain Ig-like molecule with tyrosine-based activation motifs;CD antigen CD172a;CD172 antigen-like family member A;Inhibitory receptor SHPS-1;mSIRP-alpha1;MyD-1 antigen;p84;SHP substrate 1;SHPS-1;Signal-regulatory protein alpha-1;SIRPA;Sirp-alpha-1;Tyrosine-protein phosphatase non-receptor type substrate 1

SIRPA

Neuroscience

SIRPA