Glutamate Receptor Ionotropic Nmdar2B

E2629Mo

Sandwich

48T,96T

0.032ng/ml

0.05-30ng/ml

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion Channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate Channel inhibition by Mg(2+) (PubMed: 1377365, PubMed: 26912815). Sensitivity to glutamate and Channel kinetics depend on the subunit composition (PubMed: 1377365). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor Channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (PubMed: 20141836). Contributes to neural pattern formation in the developing brain (PubMed: 8789948). Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (PubMed: 8789948).

165,959

14812

GluN2B;Glutamate [NMDA] receptor subunit epsilon-2;Glutamate receptor ionotropic, NMDA 2B;GRIN 2B;GRIN2B;NMDAR2B;N-methyl D-aspartate receptor subtype 2B;NR2B

GRIN2B

Signal Transduction

GRIN2B