Mitochondrial Amidoxime-Reducing Component 1

E2693Mo

Sandwich

48T,96T

9.96ng/L

20-4500ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.

37,979

66112

44256;Mitochondrial amidoxime-reducing component 1;Moco sulfurase C-terminal domain-containing protein 1;Molybdenum cofactor sulfurase C-terminal domain-containing protein 1;MOSC domain-containing protein 1;MTARC 1;MTARC1

MTARC1

Others

MTARC1