Chitinase-3-Like Protein 1

E0337Po

Sandwich

48T,96T

3.32ng/mL

7-1500ng/mL

Serum, plasma, cell culture supernates

Porcine

2-8ºC

1h 30m

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity). Stimulates migration and adhesion of cultured vascular smooth muscle cells.

42,800

396865

38 kDa heparin-binding glycoprotein;CHI 3L1;CHI3L1;Chitinase-3-like protein 1;gp38k;Signal-processing protein

CHI3L1

Others

CHI3L1