Full product name
Vascuoar Endothelial Cell Growth Factor Receptor 1
Code
E0248Hu
Assay type
Sandwich
Size
96T,48T
Sensitivity
0.05ng/ml
Detection range
0.1-40ng/ml
Sample type
Serum, plasma, cell culture supernates
Species
Human
Storage
2-8ºC
Assay time
1h 30m
Background
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (Ref.11). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed: 16685275). [Isoform 1]: Phosphorylates PLCG. [Isoform 2]: May function as decoy receptor for VEGFA. [Isoform 3]: May function as decoy receptor for VEGFA. [Isoform 4]: May function as decoy receptor for VEGFA. [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.
UniProt accession
MASS（Da）
150,769
GeneID
2321
Synonyms
FLT;FLT 1;FLT1;FLT-1;Fms-like tyrosine kinase 1;Tyrosine-protein kinase FRT;Tyrosine-protein kinase receptor FLT;Vascular endothelial growth factor receptor 1;Vascular permeability factor receptor;VEGFR-1
Gene names
FLT1
Research area
Cardiovascular
Target protein
FLT1
