S100 Calcium Binding Protein A4

E1341Ra

Sandwich

48T,96T

5.63ng/L

10-4000ng/L

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (By similarity). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity).

11,776

24615

Metastasin;Nerve growth factor-induced protein 42A;P9K;Placental calcium-binding protein;Protein S100-A4;S100 calcium-binding protein A4;S100A4

S100A4

Others

S100A4