Cysteine and Glycine-Rich Protein 3

E1938Ra

Sandwich

48T,96T

7.33ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (PubMed: 7954791, PubMed: 9234731). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association. In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity).

20,803

117505

CRP3;CSRP 3;CSRP3;Cysteine and glycine-rich protein 3;Cysteine-rich protein 3;LIM domain protein, cardiac;Muscle LIM protein

CSRP3

Epigenetics and Nuclear Signaling; Cardiovascular

CSRP3