E3 Ubiquitin-Protein Ligase Trim63

E1951Ra

Sandwich

48T,96T

7.56ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

39,723

140939

E3 ubiquitin-protein ligase TRIM63;MuRF1;MuRF-1;Muscle-specific RING finger protein 1;RING-type E3 ubiquitin transferase TRIM63;TRIM 63;TRIM63;Tripartite motif-containing protein 63

TRIM63

Cell Biology

TRIM63