Signal Transducer and Activator of Transcription 3

E0650Hu

Sandwich

96T,48T

0.05ng/ml

0.1-40.ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed: 10688651, PubMed: 12359225, PubMed: 12873986, PubMed: 15194700, PubMed: 17344214, PubMed: 18242580, PubMed: 23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed: 17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed: 12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed: 12359225). Activated by IL31 through IL31RA (PubMed: 15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed: 28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed: 17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed: 18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed: 23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).

88,068

6774

Acute-phase response factor;Signal transducer and activator of transcription 3;STAT 3;STAT3

STAT3

Others

STAT3