Suppressors of Cytokine Signaling 3

E0657Hu

Sandwich

96T,48T

9.02ng/L

20-6000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed: 15601820).

24,770

9021

CIS-3;Cytokine-inducible SH2 protein 3;SOCS 3;SOCS3;SOCS-3;SSI-3;STAT-induced STAT inhibitor 3;Suppressor of cytokine signaling 3

SOCS3

Signal Transduction

SOCS3