Haptoglobin/Zonulin

E1117Hu

Sandwich

48T,96T

1.09ug/ml

2-600ug/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

45,205

3240

Haptoglobin;Haptoglobin alpha chain;Haptoglobin beta chain;HP;Zonulin

HP

Cardiovascular

HP