Peroxisome Proliferator-Activated Receptor Gamma

E1511Hu

Sandwich

48T,96T

14.16ng/L

30-9000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein.

57,620

5468

Nuclear receptor subfamily 1 group C member 3;Peroxisome proliferator-activated receptor gamma;PPARG;PPAR-gamma

PPARG

Metabolism

PPARG