Pachytene Checkpoint Protein 2 Homolog

E1743Hu

Sandwich

48T,96T

5.91ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed: 28553959).

48,551

9319

16E1-BP;HPV16 E1 protein-binding protein;Human papillomavirus type 16 E1 protein-binding protein;Pachytene checkpoint protein 2 homolog;Thyroid hormone receptor interactor 13;Thyroid receptor-interacting protein 13;TR-interacting protein 13;TRIP 13;TRIP13;TRIP-13

TRIP13

Others

TRIP13