Mucin-4

E1940Hu

Sandwich

48T,96T

5.48pg/ml

10-3000pg/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

231,518

4585

Ascites sialoglycoprotein;Ascites sialoglycoprotein 1;Ascites sialoglycoprotein 2;ASGP;ASGP-1;ASGP-2;MUC 4;MUC4;MUC-4;Mucin-4;Mucin-4 alpha chain;Mucin-4 beta chain;Pancreatic adenocarcinoma mucin;Testis mucin;Tracheobronchial mucin

MUC4

Signal Transduction

MUC4