Toll-Like Receptor 2

E0422Bo

Sandwich

96T,48T

2.75ng/ml

5-1000ng/ml

Serum, plasma, cell culture supernates

Bovine

2-8ºC

1h 30m

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).

90,205

281534

CD antigen CD282;CD282;TIL4;TLR 2;TLR2;Toll like receptor 2;Toll/interleukin 1 receptor like 4;Toll-like receptor 2

TLR2

Immunology; Microbiology; Signal Transduction; Cardiovascular

TLR2