Beclin-1

E2011Hu

Sandwich

48T,96T

0.1ng/ml

0.2-60ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Plays a central role in autophagy (PubMed: 23184933, PubMed: 28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed: 20643123, PubMed: 20208530, PubMed: 26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed: 25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed: 9765397). May play a role in antiviral host defense. Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.

51,896

8678

Beclin-1;Beclin-1-C 35 kDa;Beclin-1-C 37 kDa;BECN 1;BECN1;Coiled-coil myosin-like BCL2-interacting protein;Protein GT197

BECN1

Others

BECN1