Glycyl Trna Synthetase

E2239Hu

Sandwich

48T,96T

10.03ng/L

20-4500ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed: 107$498.00|$360.0048, PubMed: 11980911). Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed: 107$498.00|$360.0048, PubMed: 11980911). Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed: 10479480). In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed: 11980911). Exhibits long-chain fatty acids (LCFA) transport activity (PubMed: 20530735). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity).

75,385

10998

BA-CoA ligase;BACS;BAL;Bile acid-CoA ligase;Bile acyl-CoA synthetase;Cholate--CoA ligase;FATP-5;Fatty acid transport protein 5;Fatty-acid-coenzyme A ligase, very long-chain 3;SLC27A5;Solute carrier family 27 member 5;Very long-chain acyl-CoA synthetase homolog 2;Very long-chain acyl-CoA synthetase-related protein;VLACSR;VLACS-related;VLCSH2;VLCS-H2

SLC27A5

Cardiovascular

SLC27A5