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Home > Product > ELISA Kit > Human Exportin 1, XPO1 ELISA Kit

Human Exportin 1, XPO1 ELISA Kit

Human Exportin 1, XPO1 ELISA Kit

Product Summary

Size: 48T,96T

Sensitivity: 10.28ng/L

Detection range: 20-3800ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Product Summary

Size: 48T,96T

Sensitivity: 10.28ng/L

Detection range: 20-3800ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Product overview

Full product name

Exportin 1

Code

E2694Hu

Assay type

Sandwich

Size

48T,96T

Sensitivity

10.28ng/L

Detection range

20-3800ng/L

Sample type

Serum, plasma, cell culture supernates

Species

Human

Storage

2-8ºC

Assay time

1h 30m

Background

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

UniProt accession

MASS(Da)

123,386

GeneID

7514

Synonyms

Chromosome region maintenance 1 protein homolog;Exp1;Exportin-1;XPO 1;XPO1

Gene names

XPO1

Research area

Others

Target protein

XPO1

Components

Components Quantity
Pre-coated ELISA Plate 12 * 8 well strips x1
Standard solution 0.5ml x1
Standard diluent 3ml x1
Streptavidin-HRP 6ml x1
Stop solution 6ml x1
Substrate solution A 6ml x1
Substrate solution B 6ml x1
Wash buffer concentrate (25x) 20ml x1
Biotinylated antibody 1ml x1

Protocol data

These standard curves of E2694Hu are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration O.D. Average Corrected
2000ng/L 2.262 2.168 2.115
2.075
1000ng/L 1.407 1.475 1.422
1.544
500ng/L 0.601 0.626 0.572
0.65
250ng/L 0.407 0.425 0.371
0.442
125ng/L 0.147 0.138 0.085
0.13
0ng/L 0.048 0.053 0
0.059

Precision

We measured random samples of E2694Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay Sample n Mean Standard Deviation CV%
Intra-Assay 1 18 1324.8 52.5 4
Intra-Assay 2 18 551.2 18.13 3.3
Intra-Assay 3 18 363.4 15 4.1

Protocols

References

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Associated products

Product size

Price

  • 48T

    $320.00

  • 96T

    $458.00

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Lead time: Within one week

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