Carbohydrate Sulfotransferase 4

E2874Hu

Sandwich

48T,96T

0.022ng/ml

0.05-20ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location.

45,134

10164

Carbohydrate sulfotransferase 4;CHST 4;CHST4;Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3;GlcNAc6ST-2;Gn6st-2;GST-3;HEC-GlcNAc6ST;High endothelial cells N-acetylglucosamine 6-O-sulfotransferase;L-selectin ligand sulfotransferase;LSST;N-acetylglucosamine 6-O-sulfotransferase 2

CHST4

Others

CHST4