Ninein/Gsk3B Interacting Protein

E3201Hu

Sandwich

48T,96T

0.05ng/ml

0.1-30ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed: 27484798, PubMed: 25920809, PubMed: 16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed: 27484798, PubMed: 16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed: 25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed: 19830702).

15,648

51527

GSK3beta interaction protein;GSK3B-interacting protein;GSKIP

GSKIP

Cell Biology

GSKIP