Oxidized Low-Density Lipoprotein Receptor 1

E3225Hu

Sandwich

48T,96T

0.022ng/ml

0.05-30ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

30,959

4973

C-type lectin domain family 8 member A;hLOX-1;Lectin-like oxidized LDL receptor 1;Lectin-like oxLDL receptor 1;Lectin-type oxidized LDL receptor 1;LOX-1;OLR 1;OLR1;Oxidized low-density lipoprotein receptor 1;Oxidized low-density lipoprotein receptor 1, soluble form;Ox-LDL receptor 1

OLR1

Cardiovascular

OLR1