Bone morphogenetic protein 4

E0266Ra

Sandwich

48T,96T

1.01ng/L

2-600ng/L

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (By similarity). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity).

46,541

25296

BMP-2B;BMP-4;BOMPR4A;Bone morphogenetic protein 2B;Bone morphogenetic protein 4

Bmp4

Cardiovascular; Signal Transduction; Cancer; Developmental Biology

BMP-4