Integrin alphaM

E0308Hu

Sandwich

48T,96T

0.014ng/ml

0.2-60ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:9558116, PubMed:20008295). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).

127,179

3684

CD antigen CD11b;CD11 antigen-like family member B;CD11B;Cell surface glycoprotein MAC-1 subunit alpha;CR-3 alpha chain;CR3A;Integrin alpha-M;ITG;Leukocyte adhesion receptor MO1;MAC-1;MAC1A;MO1A;Neutrophil adherence receptor;SLEB6

ITGAM

Others

ITG