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Home > News > Choose Our Biomarker Antibodies for Breast Cancer Research

Choose Our Biomarker Antibodies for Breast Cancer Research

Breast cancer is cancer that develops from breast tissue. Risk factors for developing breast cancer include being female, obesity, a lack of physical exercise, alcoholism, hormone replacement therapy during menopause, ionizing radiation, an early age at first menstruation, having children late in life or not at all, older age, having a prior history of breast cancer, and a family history of breast cancer. 

 

Immunohistochemical markers are often used to guide treatment decisions, to classify breast cancer into subtypes that are biologically distinct and behave differently, and both as prognostic and predictive factors. Steroid hormone receptors, markers of tumour proliferation, and factors involved in angiogenesis and apoptosis are of scientific interest. Zaha D. C. (2014).

 

Estrogen receptor/ER

Estrogen receptors are over-expressed in around 70% of breast cancer cases, referred to as "ER-positive", and can be demonstrated in such tissues using immunohistochemistry. Two hypotheses have been proposed to explain why this causes tumorigenesis, and the available evidence suggests that both mechanisms contribute.

 

progesterone/PR

Progesterone plays an important role in breast development in women. In conjunction with prolactin, it mediates lobuloalveolar maturation of the mammary glands during pregnancy to allow for milk production and thus lactation and breastfeeding of offspring following parturition. Estrogen induces expression of the PR in breast tissue and hence progesterone is dependent on estrogen to mediate lobuloalveolar development.

 

ERBB2/HER2

Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, ERBB2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. It is also frequently called HER2 (from human epidermal growth factor receptor 2) or HER2/neu.

 

Ki67

In breast cancer Ki67 identifies a high proliferative subset of patients with ER-positive breast cancer who derive greater benefit from adjuvant chemotherapy.

 

BT LAB offer a list of tools for analyzing the IHC for breast cancer research.

 

ER

PR

ERBB2/HER2

Ki67

BT-AP03075

BT-AP07375

BT-AP05900

BT-MCA0806

BT-AP03076

BT-AP07376

BT-AP05901

BT-MCA0805

BT-AP03077

BT-AP07377

BT-AP05902

BT-MCA0804

BT-AP03078

BT-MCA1056

BT-AP05903

BT-MCA0803

BT-AP03079

BT-MCA1058

BT-AP05904

BT-AP06027

BT-AP03080

BT-MCA1059

BT-AP05905

BT-AP04806

BT-MCA0500

 

BT-AP05906

 

BT-MCA0514

 

BT-AP05907

 

BT-MCA0515

 

BT-AP05908

 

BT-MCA0516

 

BT-MCA0045

 

BT-MCA0517

 

BT-MCA0672

 

BT-MCA0518

 

BT-MCA0940

 
   

BT-MCA0941

 
   

BT-MCA0942

 

 

2021/10/27

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