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Home > Product > Antibody > HIF-1 Alpha Monoclonal Antibody

HIF-1 Alpha Monoclonal Antibody

HIF-1 Alpha Monoclonal Antibody

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity:Human, Mouse, Monkey

Applications: WB, IHC-p, IF, ICC, ELISA

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity: Human,Mouse,Monkey

Applications: WB, IHC-p, IF, ICC, ELISA

Product overview

Full product name

Hypoxia-inducible factor 1-alpha

Code

BT-MCA0677

Host

Mouse

Isotype

IgG

Size

50ul,100ul

Clonality

Monoclonal

Immunogen

Purified recombinant fragment of human HIF-1α expressed in E. Coli.

Purification

Affinity purification

Concentration

1 mg/ml

Formulation

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

Storage

-20°C for one year

Background

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Uniprot accession

Molecular weight

N/A

Gene ID

Human: 3091; Mouse: 15251

Synonyms

HIF1A; BHLHE78; MOP1; PASD8; Hypoxia-inducible factor 1-alpha; HIF-1-alpha; HIF1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; bHLHe78; Member of PAS protein 1; PAS doma

Research area

Epigenetics and nuclear signaling; Cardiovascular; Cell biology; Metabolism

Target protein

HIF1A

Recommended dilution

Application Dilution
ELISA 1:10000
IF 1:200 - 1:1000
IHC 1:200 - 1:1000
WB 1:500 - 1:2000

Images

Western Blot analysis using HIF-1Alpha Monoclonal antibody against Cos7 (1) HeLa (2) Jurkat (3) RAJI (4) and NIH/3T3 (5) cell lysate.
Immunohistochemistry analysis of paraffin-embedded liver cancer tissues (left) and lung cancer tissues (right) with DAB staining using HIF-1Alpha Monoclonal antibody.
Immunofluorescence analysis of Hela cells using HIF-1Alpha Monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Protocols

Customer reviews and Q&As

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Product size

Price

  • 50ul

    $180.00

  • 100ul

    $300.00

Add to Cart

Lead time: Within one week

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