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Home > Product > Antibody > TAB2 Monoclonal Antibody

TAB2 Monoclonal Antibody

TAB2 Monoclonal Antibody

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity:Human

Applications: WB, FCM, ELISA

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Applications: WB, FCM, ELISA

Product overview

Full product name

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Code

BT-MCA1182

Host

Mouse

Isotype

IgG

Size

50ul,100ul

Clonality

Monoclonal

Immunogen

Purified recombinant fragment of human TAB2 expressed in E. Coli.

Purification

Affinity purification

Concentration

1 mg/ml

Formulation

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

Storage

-20°C for one year

Background

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants.

Uniprot accession

Molecular weight

N/A

Gene ID

Human: 23118

Synonyms

TAB2; KIAA0733; MAP3K7IP2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TAB-2; TGF-beta-activated kinase 1-binding protein 2

Research area

Signal transduction; Immunology

Target protein

TAB2

Recommended dilution

Application Dilution
ELISA 1:10000
FC 1:200 - 1:400
WB 1:500 - 1:2000

Images

Western Blot analysis using TAB2 Monoclonal antibody against HEK293 (1) and TAB2-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric analysis of HL-60 cells using TAB2 Monoclonal antibody (green) and negative control (purple).

Protocols

References

Customer reviews and Q&As

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Product size

Price

  • 50ul

    $180.00

  • 100ul

    $300.00

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Lead time: Within one week

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