Cytokine-inducible SH2-containing protein

BT-AP00396

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthetic peptide from human protein at AA range: 30-90

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Human: Q9NSE2; Mouse: Q62225; Rat: O70512;

Human: 1154; Mouse: 12700

Cytokine-inducible SH2-containing protein; CIS;CIS-1;Protein G18;Suppressor of cytokine signaling;SOCS; Cytokine-inducible SH2-containing protein; CIS; CIS-1; Protein G18; Suppressor of cytokine signaling; SOCS)

Epigenetics and nuclear signaling; Signal transduction

CISH