Insulin-like growth factor 1 receptor

BT-AP08801

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized phospho-peptide around the phosphorylation site of human IGF-IR (phospho Tyr1161)

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Human: P08069/P06213; Rat: P24062/P15127;

154793

Human: 3480; Mouse: 16001/16337; Rat: 25718

Insulin-like growth factor 1 receptor; IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221; INSR; Insulin receptor; IR; CD antigen CD220

Signal transduction; Cancer; Developmental biology

IGF1R