DAB2

BT-AP08887

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human DAB2

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.333% sodium azide.

-20°C for 1 year

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells| but is down-regulated or absent from ovarian carcinoma cell lines| suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2| an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras)| via its C-terminal proline-rich sequences| and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Human: P98082; Mouse: P98078; Rat: O88797;

Human: 1601; Mouse: 13132; Rat: 79128

DAB2; Disabled homolog 2; DOC-2; Differentially-expressed protein 2)

Epigenetics and nuclear signaling; Signal transduction

DAB2